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| 2008 | Top | |||||
| Henrickson, S.E., Mempel T.R., Mazo I.B., Liu B., Artyomov M.N., Zheng H., Peixoto A., Flynn M., Senman B., Junt T., Wong H.C., Chakraborty A.K. and von Andrian UH. In vivo imaging of T cell priming. Science Signaling 1(12):pt2, 2008. [Reprint Available Upon Request] | ||||||
| Mora, J.R. and von Andrian, U.H. Differentiation and homing of IgA-secreting cells. Mucosal Immunology [Epub ahead of print, January 23, 2008]; doi:10.1038/mi.2007.14 [Full Text PDF] | ||||||
| Henrickson, S.E., Mempel, T.R., Mazo, I.B., Liu, B., Flynn, M., Artomov, M., Junt, T., Wong, H.C., Chakraborty, A.K. and von Andrian, U.H. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nature Immunology, 9(3):282-291, 2008. [Full Text PDF][Supplementary Materials][Supplementary Videos] | ||||||
Laird, D.J., von Andrian, U.H. and Wagers, A.J. Stem cell trafficking in tissue development, growth and disease. Cell, 132(4):612-630, 2008. [Full Text PDF] |
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| 2007 | Top | |||||
| Iparraguirre, A., Tobias, J.W., Hensley, S.E., Masek, K.S., Cavanagh, L.L., Rendl, M., Hunter, C.A., Ertl, H., von Andrian, U.H. and Weninger, W. Two distinct differentiation states of plasmacytoid dendritic cells induced by influenza virus and CpG1828 oligonucleotide. J. Leuk. Biol. 83: 2007 Nov 20; [Epub ahead of print]; PMID: 18029397; DOI:10.1189/jlb.0807511. [Full Text PDF] | ||||||
| Swirski, F.K., Berger, C.R., Figueiredo, J.-L., Mempel, T.R., von Andrian, U.H., Pittet, M.J. and Weissleder, R. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS ONE 2(10):e1075; 2007 Oct 24;. PMID: 1795725. [Full Text PDF] | ||||||
| De Paz, J.L., Moseman, E.A., Noti, C., Polito, L., von Andrian, U.H. and Seeberger, P.H. Profiling heparin-chemokine interactions using synthetic tools. ACS Chem. Biol. 2(11):735-44, 2007. [Full Text PDF] | ||||||
| Gauguet, J.M., Bonasio, R. and von Andrian, U.H. High endothelial venules. In: “Endothelial Biomedicine.” Aird, W.C. (ed.). Cambridge University Press, New York, NY. pp. 1568-1588, 2007. [Full Text PDF] | ||||||
| Tenno, M., Ohtsubo, K., Hagen, F.K., Ditto, D., Zarock, A., Schaerli, P. von Andrian, U.H., Ley, K., Le, D., Tabak, L.A., Marth, J.D. Initiation of Protein O-Glycosylation by Polypeptide GalNAcT-1 in Vascular Biology and Humoral Immunity. Mol Cell Biol. 27(24):8783-96, 2007. [Full Text PDF] | ||||||
Junt, T., Schulze, H., Chen, Z., Massberg, S., Goerge, T., Krüger, A., Richardson, J., Graf, T., Italiano, J., Shivdasani, R. and von Andrian, U.H. Dynamic visualization of thrombopoiesis within bone marrow. Science, September; 317: 1767-1770, 2007. [Full Text PDF][Supporting Online Material] [Supplemental Videos] |
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Massberg. S, Schaerli, P., Knezevic-Maramica, I., Köllnberger, M., Tubo, N., Moseman E.A., Huff, I.V., Junt, T., Wagers, A.J., Mazo, I.B. and von Andrian, U.H. Physiological recirculation of haematopoietic stem and progenitor cells through blood, lymph and extramedullary tissues. Cell, November; 131(5): 994-1008, 2007. [Full Text PDF + Supplemental Materials] |
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| Junt, T., Moseman, E.A., Boes, M., Fink, K., Shayakhmetov, D.M., Mempel, T.R., Whelan, S.P. and von Andrian, U.H. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature, 2007 Oct 14; [Epub ahead of print] PMID: 17934446. [Full Text PDF + Supplemental Materials] [Supplementary Videos] | ||||||
| Bonasio, R., Carman, C.V., Kim, E., Sage, P.T., Love, K.R., Mempel, T.R., Springer, T.A. and von Andrian, U.H. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. PNAS, September; 104(37): 14753-14758, 2007. [Full Text PDF] [Supplemntal Videos] | ||||||
| Park, E.J., Mora, J.R., Carman, C.V., Chen, J.F., Sasaki, Y., Cheng, G., von Andrian, U.H. and Shimaoka M. Aberrant activation of integrin a4b7 suppresses lymphocyte migration to the gut. Journal of Clinical Investigation, 117(9):2526-2538, 2007. [Full Text PDF] | ||||||
| Hauser, A.E., Junt, T., Mempel, T.R., Sneddon, M.W., Kleinstein, S.H., Henrickson, S.E., von Andrian, U.H., Shlomchik, M.J., Haberman, A.M. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity, May; 26(5): 655-57, 2007. [Full Text PDF] | ||||||
| von Andrian, U.H. and Sallusto, F. Lymphocyte Activation. Current Opinion in Immunology, Jun;19(3): 247-8, 2007. [Full Text PDF] | ||||||
| Henrickson, S.E. and von Andrian, U.H. Single-cell dynamics of T cell priming. Current Opinion in Immunology, Jun;19(3): 249-58, 2007. [Full Text PDF] | ||||||
| Friedl, P., Wolf, K., Harms, G. and von Andrian, U.H. Biological second and third harmonic generation microscopy. Current Protocols in Cell Biology, Unit 4.15: Published online, March 2007; DOI: 10.1002/0471143030.cb0415s34. | ||||||
| Li, J., Brieher, W.M., Scimone M.L., Kang, S.J., Zhu, H., Yin, H., von Andrian, U.H., Mitchison, T. and Yuan, J. Caspase-11 regulates cell migration by promoting Aip1/Cofilin-mediated actin depolymerization. Nature Cell Biology, 9(3):276-286, 2007. [Full Text PDF] | ||||||
Worbs, T., Mempel, T.R., Bölter, J., von Andrian, U.H. and Förster, R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. Journal of Experimental Medicine, 204(3):489-495, 2007. [Full Text PDF] |
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| Nombela-Arrieta, C., Mempel, T.R., Soriano, S.F., Mazo, I.B., Wymann, M.B., Hirsch, E., Martínez, C., Fukui, T., von Andrian, U.H. and Stein, J.V. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. Journal of Experimental Medicine, 204(3):497-510, 2007. [Full Text PDF] | ||||||
| Mitoma, J., Bao, X., Petryanik, B., Schaerli, P., Garguet, J.-M., Yi, S., Kawashima, H., Saito, H., Ohtsubo, K., Marth, J.D., Khoo, K.-H., von Andrian, U.H., Lowe, J.B. and Fukuda, M. Novel roles of N-glycan-based L-selectin ligands in lymphocyte homing and recruitment. Nature Immunology, 8(4):409-418, 2007. [Full Text PDF] | ||||||
| Meuter, S., Schaerli, P., Stuber Roos, R., Brandau, O., Fässler, R., von Andrian, U.H. and Moser, B. Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues. Molecular and Cellular Biology, 27(3):983-992, 2007. [Full Text PDF] | ||||||
| Yano, K., Daniel Gale, D., Massberg, S., Cheruvu, P.K., Monahan-Earley, R., Morgan, E.S., Haig, D., von Andrian, U.H., Dvorak, A.M. and Aird, W.C. Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium. Blood, 109:613-615, 2007. [Full Text PDF] | ||||||
| 2006 | Top | |||||
| Mempel, T.R., Junt, T. and von Andrian, U.H. Rulers over randomness: Stroma cells guide lymphocyte migration in lymph nodes. Immunity, 25(6): 867-869, 2006. [Full Text PDF] | ||||||
| Mora, J.R., Iwata, M., Eksteen, B., Song, S.-Y., Junt, T., Senman, B., Otipoby, K.L., Ricciardi-Castagnoli, P., Rajewsky, K., Adams, D.H. and von Andrian, U.H. Intestinal dendritic cells generate gut-homing IgA-secreting B cells. Science, 314: 1157-1169, 2006. [Full Text PDF] [Supplemental Online Data][Full Text PDF and Supplemental Data] | ||||||
| Chen, Q., Fisher, D.T., Clancy, K.A., Gauguet, J.-M., Wang, W.C., Unger, E., Rose-John, S., von Andrian, U.H., Baumann, H. and Evans, S.S. Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules through an IL-6 trans-signaling mechanism. Nature Immunology; 7(12):1299-1308, 2006. [Full Text PDF] | ||||||
| Mrass, P., Takano, H., Daxini, S., Lasaro, M., Iparraguirre, A., Cavanagh, L.L., von Andrian, U.H., Ertl, H.C.J., Haydon, P.G. and Weninger, W. Random migration precedes stable target cell interactions of tumour infiltrating T cells. Journal of Experimental Medicine, 203(12):2749-61, 2006. | ||||||
Krause, D.S., Lazarides, K., von Andrian, U.H. and Van Etten, R.A. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nature Medicine, 12(10):1175-80, 2006. [Full Text PDF] |
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| Massberg, S. & von Andrian, U. H. Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration. New England Journal of Medicine, 355, 1088-91 (2006). [Full Text PDF] | ||||||
Bonasio, R., Scimone, M.L., Schaerli, P., Grabie, N., Lichtman, A.H. and von Andrian, U.H. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nature Immunology, 7, 1092-100 (2006). [Full Text PDF] |
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| Pearce, G., Angeli, V., Randolph, G.J., Junt, T., von Andrian, U., Schnittler, H.-J. and Jessberger, R. Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs. Nature Immunology, 7(8): 827-834. [Full Text PDF] [Supplementary Material PDF] | ||||||
| Bonasio, R., and von Andrian, U.H. Generation, migration and function of circulating dendritic cells. Current Opinion in Immunology, 18: 1-9, 2006 [Full Text PDF] | ||||||
| Mempel, T.R., Pittet, M.J., Khazaie, K., Weninger, W., Weissleder, R., von Boehmer, H., von Andrian, U.H., Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity, 25(1): 129-141, 2006. [Full Text PDF] [Supplementary Material PDF] [Supplementary Videos] | ||||||
| Scimone, M.L., Aifantis, I., Campbell, J.J., von Boehmer, H. and von Andrian, U.H. A multi-step adhesion cascade for lymphoid progenitor cell homing to the thymus. Proceedings of the National Academy of Science, 103(18): 7006-11, 2006 . [Full Text PDF] | ||||||
| O'Leary J.G., Goodarzi M, Drayton D.L., von Andrian, U.H. T cell- and B cell-independent adaptive immunity mediated by natural killer cells , Nature Immunology, 7: 507-516, 2006. [Full Text PDF] | ||||||
| Mora, J.R. and von Andrian, U.H. T-cell specificity and plasticity: new concepts and future challenges. Trends in Immunology, 2006 May; 27(5):235-43. Epub 2006 Mar 31. [Full Text PDF] | ||||||
| Mora, J.R. and von Andrian, U.H. Specificity and plasticity of memory lymphocyte migration. Current Topics in Microbiology and Immunology. “Gut-Associated Immune System”, Melchers F. and Honjo T. (eds.). Springer-Verlag Berlin Heidelberg New York Tokyo. 308: 83-116, 2006. [Full Text PDF] | ||||||
| Wang J, Fathman JW, Lugo-Villarino G, Scimone L, von Andrian U, Dorfman DM, Glimcher LH. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. The Journal of Clinical Investigation, 116(2): 414-21, 2006. [Full Text PDF] | ||||||
| 2005 | Top | |||||
| Cariappa, A., Mazo, I.B., Chase, C., Shi, H.N., Liu, H., Li, Q., Rose, H., Leung, H., Cherayil, B.J., Russell, P., von Andrian, U.H., and Pillai, S. Perisinusoidal B cells in the bone marrow mediate T-independent IgM responses to blood-borne microbes. Immunity, 23(4): 397-407, 2005. [Full Text PDF] [Supplementary Material PDF] [Supplemental Video 1] [Supplemental Video 2] | ||||||
| Uchimura, K., Gauguet, J.-M., Singer, M.S., Tsay, D., Kannagi, R., Muramatsu, T., von Andrian, U.H. and Rosen, S.D. A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules . Nature Immunology, 6(11): 1105-13, 2005. [Full Text PDF] | ||||||
| Luster, A.D., Alon, R. and von Andrian, U.H. Immune cell migration in inflammation: present and future therapeutic targets. Nature Immunology, 6(12): 1182 - 1190, 2005. [Full Text PDF] | ||||||
| Cavanagh, L.L., Bonasio, R., Mazo, I.B., Halin, C., van der Velden, A.W.M., Cariappa, A., Chase. C., Russell, P., Starnbach, M.N., Leung, H., Pillai, S., Weninger, W., and von Andrian, U.H. Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nature Immunology, 6(10): 1029-37, 2005. [Full Text PDF] [Video 1: 2.8MB] [Video 2: 2.9MB] | ||||||
| Halin, C., Mora, J.R., Sumen, C. and von Andrian, U.H. In vivo imaging of lymphocyte trafficking. Annual Review of Cell and Developmental Biology, 21: 581-603, 2005. [Full Text PDF] | ||||||
| Halin, C., Scimone, M.L., Gauguet, J.-M., Mempel, T.R., Quackenbush, E.J., Proia, R., Mandala, S. and von Andrian, U.H. The S1P-analog FTY720 differentially modulates T cell homing via HEV: T cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer’s patches. Blood, 106(4): 1314-1322, 2005. [Abstract] [Full Text PDF] [Supplemental Video] |
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| Lauer, J.L., Shohet, L.J., Albrecht, R.M., Esnault, S., Malter, J.S., von Andrian, U.H., and Shohet, S.B. Control of uniformity of plasma-surface modification inside of small-diameter polyethylene tubing using microplasma diagnostics. IEEE Transactions on Plasma Science, 33(2): April 2005. [Full Text PDF] | ||||||
| Shamri, R., Grabovsky, V., Gauguet, J.-M., Feigelson, S., Manevich, E., Kolanus, W., Staunton, D.E., von Andrian, U.H., and Alon, R. Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nature Immunology, 6(5): 497 - 506, 2005. [Abstract] [Full Text PDF] | ||||||
| Snapper, S.B, Meelu, P., Nguyen, D., Stockton, B.M., Bozza, P., Alt, F.W., Rosen, F.S., von Andrian, U.H., and Klein, C. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. J Leukoc Biol. 2005 Jun; 77(6):993-8. [Abstract] [Full Text PDF] | ||||||
| Mazo, I.B., Honczarenko, M., Leung, H., Cavanagh, L.L., Bonasio, R., Weninger, W., McEver, R., Koni, P.A., Silberstein, L.E. and von Andrian, U.H., Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity. 22:259-270, 2005. [Abstract] [Full Text PDF] [Guide to Supplemental Videos] | ||||||
| Supplemental Videos: | ||||||
| [Video 1: 2.1MB] [Video 2: 596KB] [Video 3: 26MB] [Video 4: 8.7MB] | ||||||
Mora, J.R., Cheng, G., Picarella, D.,
Briskin, M., Buchanan, N. and von Andrian, U.H. Reciprocal
and dynamic control of CD8 T cell homing by dendritic
cells from skin-and gut-associated lymphoid tissues. Journal of Experimental Medicine, 201: 303-316, 2005. |
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| [Abstract] [Full Text PDF] [Supplementary Material PDF][Cover] | ||||||
| Gauguet, J.M., Bonasio, R. and von Andrian, U.H. High endothelial venules. In: “Endothelial Cells in Health and Disease.” Aird, W.C. (ed.). Taylor & Francis, Boca Raton, FL. pp. 77-103, 2005. | ||||||
| 2004 | Top | |||||
| Mora, J.R. and von Andrian, U.H. Retinoic Acid: An educational “vitamin elixir” for gut-seeking T cells. Immunity. 21(4): 458-60, 2004. [Abstract] [Full Text PDF] | ||||||
| Bergmeier, W., Piffath, C., Cheng, G., Dole, V., Zhang, Y., von Andrian, U.H. and Wagner, D.D. Tumor necrosis factor-a-converting enzyme (ADAM 17) mediates shedding of GPIba in platelets. Circ. Res. 95(7):677-683 , 2004. [Abstract] [Full Text PDF] | ||||||
| Sumen, C., Mempel, T.R., Mazo, I.B. and von Andrian, U.H. Intravital microscopy - visualizing immunity in context. Immunity 21(3): 315-329, 2004. | ||||||
| [Abstract] [Full Text PDF] [Guide to Supplemental Videos] | ||||||
| Supplemental Videos: | ||||||
| [Video 1: 792KB] [Video 2: 1.5MB] [Video 3: 1.3MB] [Video 4: 1.5MB] [Video 5: 792KB] [Video 6: 372KB] | ||||||
| [Video 7: 820KB] [Video 8: 1.5MB] [Video 9: 1MB] [Video 10: 12.3MB] [Video 11: 9MB] [Video 12: 4.5MB] | ||||||
| Stokol, T., Xiao, L., Stavrakis, G., Botto, M., von Andrian, U.H. and Mayadas, T.N. Complement C1q governs deposition of circulating immune complexes and leukocyte FcgRs mediate subsequent neutrophil recruitment. J. Exp. Med. 200(7): 835-846, 2004. [Abstract] [Full Text PDF] | ||||||
| Gauguet, J.M., Rosen, S.D., Marth, J.D., and von Andrian, U.H. Core 2 branching ß1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B and T lymphocyte homing to peripheral lymph nodes. Blood 104(13):4104-4122, 2004. [Abstract] [Full Text] | ||||||
| Mempel, T.R., Scimone, L.M., Mora, J.R., and von Andrian, U.H. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Current Opinion in Immunology 16: 406-417, 2004. [Abstract] [Full Text PDF] | ||||||
| Williams, C.J., Naito, T., Cashman, S.M., Gomez-del Arco, P., DeSouza, B., Keables, P., von Andrian, U.H. and Georgopoulos, K. The chromatin remodeler Mi-2ß is required for CD4 expression during T cell development. Immunity 20(6):719-733, 2004. [Abstract] [Full Text PDF] | ||||||
| Lauer, J.L., Shohet, J.L., Albrecht, R.M., Pratoomtong, C., Murugesan, R., Esnault, S., Malter, J.S., von Andrian, U.H., Bathke, R.D. and Shohet, S.B. Reduced adhesion of human blood platelets to polyethylene tubing by microplasma surface modification. J. Applied Physics 96(8): 4539-4546, 2004 [Full Text PDF] | ||||||
| Rot, A. and von Andrian, U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 22: 891-928, 2004. [Abstract] [Full Text PDF] | ||||||
| Scimone, M.L., Felbinger, T.W., Mazo, I.B., von Andrian, U.H., and Weninger, W. CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. J. Exp. Med. 199(9): 1113-1120, 2004. [Abstract] [Full Text PDF] | ||||||
| Ludwig, R.J., Schultz, J.E., Boehncke, W.H., Podda, M., Tandi, C., Krombach, F., Baatz, H. Kaufmann, R., von Andrian, U.H. and Zollner, T.M. Activated but not resting platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules. J. Invest. Dermatol. 122: 830-836, 2004. [Abstract] [Full Text PDF] | ||||||
| Scimone, M.L. and von Andrian, U.H. Immunological homing and adhesion molecules. In: Encyclopedia of Life Sciences. Macmillan Reference Limited, Stockton Press, London, 2004. URL: http://www.els.net/elsonline/ | ||||||
| Salas, A., Shimaoka, M., Kogan, A.N., Harwood, C., von Andrian, U.H., and Springer, T.A. Rolling adhesion through an extended conformation of integrin alphaLß2 and relation to alpha I and ß I-like domain interaction. Immunity 20(4): 393-406, 2004. [Abstract] [Full Text PDF] | ||||||
Mempel, T.R., Henrickson, S.E. and von Andrian, U.H. T cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159, 2004. |
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| Supplemental Videos: | ||||||
| Video 1: 5.6MB ] [Video 2: 5.8MB ] [Video 3: 12.7MB] [Video 4: 5.6MB ] [Video 5: 2.3MB ] [Video 6: 7.2MB ] [Video 7: 4.7MB ] [Video 8: 13.8MB ] [Video 9: 3.4MB ] | ||||||
| Cyster, J.G. and von Andrian, U.H. Dynamics of B cell migration to and within secondary lymphoid organs. In: "Molecular Biology of B Cells". Honjo, T., Alt, F.A., and Neuberger, M. (eds.). Elsevier Academic Press: pp 203-221, 2004. | ||||||
| 2003 | Top | |||||
|
von Andrian, U.H. Introduction: Chemokines – Regulation of Immune Cell Trafficking and Lymphoid Organ Architecture. Seminars in Immunology 15(5): 239-241, 2003. [Full Text PDF] |
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| Weninger, W. and von Andrian, U.H. Chemokine regulation of naïve T cell traffic in health and disease. Seminars in Immunology 15(5): 257-270, 2003. [Full Text PDF] | ||||||
| M'Rini, C., Cheng, G., Schweitzer, C., Cavanagh, L.L., Palframan, R.T., Mempel, T., Warnock, R.A., Lowe, J.B., Quackenbush, E.J., and von Andrian, U.H. A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha (1,3)-fucosyltransferase-IV. J. Exp. Med. 198(9): 1301-1312, 2003. | ||||||
| Article: [Abstract] [Full Text PDF] [Suppl. Fig. 1] | ||||||
| Suppl. Videos: [Video 1: 4MB] [Video 2: 2MB] [Video 3: 800KB] [Video 4: 2.3MB] [Video 5: 132KB] | ||||||
| Wan, J., Martinvalet, D., Ji X., Lois C., Kaech, S.M., von Andrian, U.H., Lieberman, J., Ahmed, R., and Manjunath, N. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. Immunology 110(1): 10-17, 2003. [Abstract] | ||||||
| Goodarzi, K., Goodarzi, M., Tager, A.M., Luster, A.D., and von Andrian, U.H. Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nature Immunology 4(10): 965-973, 2003. [Abstract] [Full Text PDF] | ||||||
| van Zante, A., Gauguet, J.-M., Bistrup, A., Tsay, D., von Andrian, U.H., and Rosen, S.D. Genetic deletion of a HEV-restricted sulfotransferase reveals MECA79-independent lymphocyte rolling and recruitment to lymph nodes. J. Exp. Med. 198(9): 1289-1300, 2003. [Abstract] [Full Text PDF] | ||||||
| von Andrian, U.H. and Mempel, T. Homing and Cellular Traffic in Lymph Nodes. Nature Reviews Immunology 3: 867-878, 2003. [Abstract] [Full Text PDF] | ||||||
| Suppl. Videos: [Video 1: 5MB] [Video 2: 4MB] [Video 3: 3MB] | ||||||
| Martin, C., Aifantis, I., Scimone, L., von Andrian, U.H., Reizis, B., von Boehmer, H., and Gounari, F. Efficient thymic immigration of B220(+) lymphoid-restricted bone marrow cells with T precursor potential. Nature Immunology: 4(9):866-873, 2003. | ||||||
| Robert, C., Klein, C., Cheng, G., Kogan, A.N., Mulligan, R.C., von Andrian, U.H., and Kupper, T.S. Gene therapy to target dendritic cells from blood to lymph nodes. Gene Therapy, 10(17): 1479-1486, 2003. [Abstract] [Full Text PDF] | ||||||
| Mora, J.R., Bono, R. B., Manjunath, N., Weninger, W., Cavanagh, L., Rosemblatt, M., and von Andrian, U.H. Selective imprinting of gut-homing T cells by Peyer's Patch Dendritic Cells. Nature, 424: 88-93, 2003. [Abstract] [Text Only PDF] [Supplementary Material PDF] | ||||||
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Weninger W, Carlsen HS, Goodarzi M, Moazad F, Baekkevold ES, Cavanagh LL, von Andrian UH. Naive T cell recruitment to non-lymhoid tissues: a role for endothelium-expressed CCL21 in autoimmune disease and lymphoid neogenesis. J. Immunol. 170(9): 4638-4648, 2003. [Abstract] [Full Text PDF] |
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| von Andrian, U.H. and Engelhardt, B. Alpha 4 integrins in autoimmune disease. New Eng. J. Med., 348: 68-72, 2003. [Full Text PDF] | ||||||
| Wherry, E.J., Teichgräber, V., Becker, T.C., Masopust, D., Kaech, S.M., Antia, R., von Andrian, U.H. and Ahmed, R. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunol. 4(3): 225-234, 2003. [Abstract] [Full Text PDF] | ||||||
| Wolf, K., Mazo, I., Leung, H., Engelke, K., von Andrian, U.H., Deryugina, U.I., Strongin, A.Y., Bröcker, E.B. and Friedl, P. Mesenchymal-to-ameboid transition in migrating tumor cells after blocking of matrix proteases. J. Cell Biol.160: 267-277, 2003. [Abstract] [Full Text PDF] | ||||||
| Hoffmeister, K.M., Felbinger, T.W., Falet, H., Denis, C.V., Bergmeister, W., Mayadas, T., von Andrian, U.H., Wagner, D.D., Stossel, T.P. and Hartwig, J.H. The mechanism behind the rapid clearance of chilled blood platelets. Cell 112: 87-97, 2003. [Abstract] [Full Text PDF] | ||||||
| 2002 | Top | |||||
| Cavanagh, L.L. and von Andrian, U.H. Travellers in many guises: The origins and destinations of dendritic cells. Immunol. Cell Biol. 80(5): 448-462, 2002 [Abstract] [Full Text PDF] | ||||||
| Román, E., Miller, E., Harmsen, A., Wiley, J., von Andrian, U.H., Huston, G., and Swain, S. CD4 effector T cell subsets in the response to influenza: hetergeneity, migration and function. J. Exp. Med. 196: 957-968, 2002. [Abstract] [Full Text PDF] | ||||||
| Weninger, W., Manjunath, N., & von Andrian, U.H. Migration and differentiation of CD8+ T cells. Immunol. Reviews 186(1):221-33, 2002. [Abstract] [Full Text PDF] | ||||||
| von Andrian, U.H. T cell activation in six dimensions. Science 296: 1815-1817, 2002. [Abstract] [Full Text] | ||||||
| Kogan, A.N. and von Andrian, U.H. Adhesion and communication between lymphocytes and endothelial cells. In: “Molecular Basis of Microvascular Disorders”. Schmid-Schönbein, G.W. and Granger, D.N. (eds.). Springer Verlag; pp. 97-133, 2002. | ||||||
| Lange-Asschenfeldt, B., Weninger, W., Velasco, P., von Andrian, U.H., Bornstein. P and Detmar, M. Increased and persistent inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2 deficient mice. Blood. 99(2):538-545, 2002. [Abstract] [Full Text PDF] | ||||||
| 2001 | Top | |||||
| Mazo, I.B., Quackenbush, E.J., Lowe, J.B. and von Andrian, U.H. Total body irradiation causes profound changes in endothelial traffic molecules for hematopoeitic progenitor cell recruitment to bone marrow. Blood 99: 4182-4191, 2001. [Abstract] [Full Text PDF] | ||||||
| Palframan, R.T., Jung, S., G. Cheng, G., Luo, Y., Dorf, M., Littman, D., Rollins, B., Zweerink, H., Rot, A. and von Andrian, U. H. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med. 194(9): 1361-1373, 2001. [Abstract] [Full Text PDF] | ||||||
| Weninger, W., Crowley, M.A., Manjunath, N. and von Andrian U.H. Migratory properties of naïve, effector, and memory CD8+ T cells. J. Exp. Med. 194(7): 953-966, 2001. [Abstract] [Full Text PDF] [See T Cell Images Click Here] | ||||||
| Fors, B.P., Goodarzi, K., Stein, J.V. and von Andrian U.H. L-selectin shedding is independent of subsurface structures and topography. J. Immunol. 167(7): 3642-3651, 2001. [Abstract] [Full Text PDF] | ||||||
| Manjunath, N., Shankar, P., Wan, J., Weninger, W., Crowley, M.A., Hieshima, K., Springer, T.A., Fan, X., Shen, H., Lieberman, J. and von Andrian, U.H. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J. Clin.Invest. 108: 871-878, 2001. [Abstract] [Full Text PDF] | ||||||
| Shimaoka, M., Lu, C., Palframan, R., von Andrian, U.H., Takagi, J. and Springer, T.A. Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin aL I- domains with high affinity and antagonist activity in vivo. Proc. Natl. Acad. Sci. USA 98(11):6009-6014, 2001. [Abstract] [Full Text PDF] | ||||||
| Weiler H, Lindner V, Kerlin B, Isermann BH, Hendrickson SB, Cooley BC, Meh DA, Mosesson MW, Shworak NW, Post MJ, Conway EM, Ulfman LH, von Andrian UH, Weitz JI. Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol. 21(9): 1531-7, 2001. [Abstract] [Full Text PDF] | ||||||
| Homeister, J.W., Thall, A.D., Petryniak, B., Maly, P., Rogers, C.E., Smith, P.L., Kelly, R.J., Askari, S.W., Cheng, G., Smithson, G., Marks, R.M., Misra, A.K., Hindsgaul, O., von Andrian, U.H., and Lowe, J.B. The a(1,3)fucosyltransferases Fuc-TIV and Fuc-TVII co-dominantly control E-, P-, and L-selectin ligand activities on leukocytes and high endothelial venules. Immunity 15(1):115-26, 2001. [Abstract] [Full Text PDF] | ||||||
| Baekkevold, E.S., Yamanaka, T., Carlsen, H.S., Palframan, R., Carlsen, H.S., Reinholt, F.P., von Andrian, U.H., Brandtzaeg, P. and Haraldsen G. The CCR7-ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J. Exp. Med. 193 (9): 1105-1111, 2001.[Abstract] [Full Text PDF] | ||||||
| von Andrian, U.H. PKC-ß(I) – the whole ignition system or just a sparkplug in T cell locomotion? Nature Immunology. 2(6): 6-7, 2001. [Abstract] [Full Text PDF] | ||||||
| Mackay, C.R. and von Andrian, U.H. Memory Tcells – local heroes in the struggle for immunity. Science 291: 2323-2324, 2001. [Full Text PDF] | ||||||
| von Andrian, U.H. and Mackay, C.R. The diversity of T cells. New Eng. J. Med. 344 (3): 231, 2001. [Full Text PDF] | ||||||
| 2000 | Top | |||||
| von Andrian, U.H. and Mackay, C. T cell function and migration – two sides of the same coin. New Eng. J. Med. 343(14): 1020-1034, 2000. [Abstract] [Full Text PDF] | ||||||
| Tager, A.M., Dufour, J.H., Goodarzi, K., Bercury, S.D., von Andrian, U.H., and Luster, A.D. BLTR mediates leukotriene B4-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. J. Exp. Med. 192: 439-446, 2000. [Abstract] [Full Text PDF] | ||||||
| Weninger, W., Ulfman, L.H., Cheng, G., Souchkova, N., Quackenbush, E.J., Lowe, J.B., and von Andrian, U.H. Specialized Contributions by alpha(1,3)-Fucosyltransferase-IV and FucT-VII during Leukocyte Rolling in Dermal Microvessels. Immunity 12: 665-676, 2000. [Abstract] [Full Text PDF] | ||||||
| Stein, J.V., Rot, A., Manjunath, N., Nakano, H., Luo, Y., Quackenbush, E.J., Gunn, M.D., Matsuzawa, A., Dorf, M.E., and von Andrian, U.H. The CC Chemokine TCA-4 (SLC, 6Ckine, Exodus-2) triggers LFA-1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J.Exp. Med. 191: 61-75, 2000. [Abstract] [Full Text PDF] | ||||||
| Salgia, R., Quackenbush, E., Lin, J., Souchkova, N., Sattler, M., Ewaniuk, D.S., Kulcher, K.M., Daley, G.Q., Kraeft, S.K., Sackstein, R., Alyea, E.P.III, von Andrian, U.H., Chen, L.B., Gutierrez-Ramos, J.C., Pendergrast, A.M., and Griffin, J.D. The BCR/ABL oncogene alters the chemotactic response to SDF-1a. Blood 95(9): 2913-2921, 2000. [Abstract] [Full Text PDF] | ||||||
| von Andrian, U.H. The immunoglobin superfamily in leukocyte recruitment. In: Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery. T. Collins (ed.). Kluwer Academic Publishing, Norwell, MA; pp. 55-107, 2000. | ||||||
| 1999 | Top | |||||
| Manjunath, N., Shankar, P., Stockton, B., Dubey, D., Lieberman, J., and von Andrian, U.H. A transgenic mouse model to analyze CD8+ effector T cell differentiation in vivo. PNAS 96: 13932-13937, 1999. [Abstract] [Full Text PDF] | ||||||
| Mazo, I.B. and von Andrian, U.H. Adhesion and homing of blood-borne cells in bone marrow microvessels. J. Leuk. Biol. 66: 25-32, 1999. [Abstract] [Full Text PDF] | ||||||
| Robert, C., Fuhlbrigge, R.C., Kieffer, J.D., Ayehunie, S., Cheng, G., von Andrian, U.H., and Kupper, T.S. Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance. J. Exp. Med. 189: 627-636, 1999. [Abstract] [Full Text PDF] | ||||||
| Stein, J.V., Cheng, G., Stockton, B.M., Fors, B.P., Butcher, E.C., and von Andrian, U.H. L-selectin-mediated leukocyte adhesion in vivo: microvillous distribution determines tethering efficiency, but not rolling velocity. J. Exp. Med. 189: 37-50, 1999. [Abstract] [Full Text PDF] | ||||||
| 1998 | Top | |||||
| Shohet, S.B., Bernard, M.D., Thevenin, J.-M., Sherman, I.W., and von Andrian, U.H. Newer facets of sickle cell disease adhesiveness. Cell. Molec. Biol. Letters 3: 413-422, 1998. | ||||||
| Frenette, P.S., Subbarao, S., Mazo, I.B., von Andrian, U.H., and Wagner, D.D. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc. Natl. Acad. Sci. USA 95(24): 14423-14428, 1998. [Abstract] [Full Text PDF] | ||||||
| Mazo, I.B., Guttierrez-Ramos, J.-C., Frenette, P., Wagner, D.D., Hynes, R.O., and von Andrian, U.H. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and VCAM-1. J. Exp. Med. 188: 465-474, 1998. [Abstract] [Full Text PDF] | ||||||
| von Andrian, U.H. and M'Rini, C. In Situ analysis of lymphocyte homing to lymph nodes. Cell Adh. Communic. 6: 85-96, 1998. [Abstract] | ||||||
| M.Rini, C. and von Andrian, U.H. Le recrutement des lymphocytes dans les ganglions lymphatiques: apports de la microscopie réalisée in situ sur animal vivant [French]. Hématologie 4: 180-189, 1998. | ||||||
| Stockton, B.M., Ardman, B., Cheng, G., Manjunath, N., and von Andrian, U.H. Negative regulation of T cell homing by CD43. Immunity 8: 373-381, 1998. [Abstract] [Full Text PDF] | ||||||
| Warnock, R.A., Askari, S., Butcher, E.C., and von Andrian, U.H. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J. Exp. Med. 187: 205-216, 1998. [Abstract] [Full Text] | ||||||
| Diacovo, T.G., Catalina, M.D., Siegelman, M.H., and von Andrian, U.H. Circulating activated platelets reconstitute lymphocyte homing and peripheral immunity in L-selectin deficient mice. J. Exp. Med. 187: 197-204, 1998. [Abstract] [Full Text PDF] | ||||||
| 1997 | Top | |||||
| von Andrian, U.H. A massage for the journey - keeping leukocytes soft and silent [Commentary]. Proc. Natl. Acad. Sci. 94: 4825-4827, 1997. [Abstract] [Full Text PDF] | ||||||
| 1996 | Top | |||||
| Coxon, A., Barkalow, F.J., Askari, S., Rieu, P., Sharpe, A., von Andrian, U.H., Arnaout, M.A., and Mayadas, T. A novel role for the ß2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5: 653-666, 1996. [Abstract] [Full Text PDF] | ||||||
| Stoddart, J.H.Jr., Jasuja, R.R., Sikorski, M.A., von Andrian, U.H., and Mier, J.W. Protease-resistant L-selectin mutants: down-modulation by crosslinking but not cellular activation. J. Immunol. 157: 5653-5659, 1996. [Abstract] | ||||||
| Thiel, M., Zourelidis, C., Chambers, D., Holzer, K., von Andrian, U.H., and Arfors, K.-E. Enhanced expression of ß2 integrins and shedding of L-selectin of polymorphonuclear leukocytes in septic patients. In: The Immune Consequences of Trauma, Shock and Sepsis - Mechanisms and Therapeutic Approaches. Vol. 1. E. Faist A.E. Baue, F.W. Schildberg (eds.). - Lengerich; Berlin; Düsseldorf; Riga; Scottsdale, AZ (USA); Wien; Zagreb. Pabst Science Publishers 1996. | ||||||
| Maly, P., Thall, A.D., Petryniak, B., Rogers, C.E., Smith, P.L., Marks, R.M., Kelly, R.J., Gersten, K.M., Cheng, G., Saunders, T.L., Camper, S.A., Camphausen, R.T., Sullivan, F.X., Isogai, Y., Hindsgaul, O., von Andrian, U.H., and Lowe, J.B. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell 86 (3): 643-653, 1996. [Abstract] [Full Text PDF] | ||||||
| Diacovo, T.G., Puri, K.D., Springer, T.A., and von Andrian, U.H. Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273: 252-255, 1996. [Abstract] | ||||||
| von Andrian, U.H. Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation 3(3): 287-300, 1996. | ||||||
| Finger, E.B. Puri, K.D., Alon, R., Lawrence, M.B., von Andrian, U.H., and Springer, T.A. Adhesion through L-selectin requires a threshold hydrodynamic shear. Nature 379: 266-169, 1996. [Abstract] | ||||||
| 1995 | Top | |||||
| Hasslen, S.R., von Andrian, U.H., Butcher, E.C., Nelson, R.D., and Erlandsen, S.L. Spatial distribution of L-selectin (CD62L) on human lymphocytes and transfected murine L1-2 cells. Histochem. J., 27, 547-554, 1995. [Abstract] | ||||||
| von Andrian, U.H., Hasslen, S.R., Nelson, R.D., Erlandsen, S.L., and Butcher, E.C. A central role for microvillous receptor presentation in leukocyte adhesion under flow. Cell 82: 989-999, 1995. [Abstract] | ||||||
| Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., and Butcher, E.C. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80: 413-422, 1995. [Abstract] | ||||||
| Ley, K., Tangelder, G.J., and von Andrian, U.H. Modulation of leukocyte rolling in vivo. In: Physiology and Pathophysiology of Leukocyte Adhesion. Granger, D.N. and Schmid-Schönbein, G. (eds.). Oxford University Press, New York, Oxford, 217-240, 1995. | ||||||
| 1994 | Top | |||||
| Sriramarao, P., von Andrian, U.H., Butcher, E.C., Bourdon, M.A., and Broide D.H. L-selectin and VLA-4 integrin mediate early events of eosinophil adhesion at physiologic shear rates in vivo. J. Immunol., 153: 4238-4246, 1994. [Abstract] | ||||||
| Olofsson, A.M., Arfors, K.-E., Ramezani, L., Butcher, E.C., and von Andrian, U.H. E-selectin mediates leukocyte rolling in IL-1 treated rabbit mesentary venules. Blood 84(4): 2749-2758, 1994. | ||||||
| Lehr, H.-A., Olofsson, A.M., Care, T.E., Vajkoczy, P., von Andrian, U.H., Hübner, C., Berndt, M.C., Steinberg, D., Messmer, K., and Arfors, K.-E. P-selectin mediates the interaction of circulating leukocytes with platelets and endothelium in response to oxidized LDL in vivo. Lab. Invest. 71: 380-386, 1994. [Abstract] | ||||||
| 1993 | Top | |||||
| von Andrian, U.H. and Arfors, K.-E. Neutrophil-endothelial cell interaction in vivo: a chain of events characterized by distinct molecular mechanisms. In: Inflammatory Disease Therapy. R.J. Bonney, N.S. Doherty, B.W. Morgan, and A.F. Welton (eds.). Birkhauser Verlag, Basel. Agents and Actions Suppl. 41: 153-164, 1993. | ||||||
| Baethmann, A., Kempski, O., von Andrian, U., Schürer, L., Heirler, F., Schneider, G.H., Peters, J., and Staub, F. Role of transmitters and metabolites -significance of glutamate and lactic acid in barrier disturbances and cytotoxic brain edema. In: CNS Barriers and Modern CSF Diagnostics. K. Felgenhauer, M. Holzgraefe, and H.W. Pranger (eds.) VCH, Weinheim, 153-160, 1993. | ||||||
| Picker, L., von Andrian, U.H., Burns, A.R., Doerschuk, C.M., Arfors, K.-E., and Butcher, E.C. PMN extravasation in acute inflammation: a role for selectin interaction in initial PMN-endothelial cell recognition. In: Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion. P.E. Lipsky, R. Rothlein, T.K. Kishimoto, R.B. Faanes, and C.W. Smith (eds.), Springer-Verlag, New York, 151-167, 1993. | ||||||
| von Andrian, U.H., Chambers, J.D., Berg, E.L., Michie, S.A., Brown, D.A., Karolak, D., Remezani, L., Berger, E.M., Arfors, K.-E., and Butcher, E.C. L-selectin mediates neutrophil rolling in inflamed venules through siayl-Lewisx-dependent and -independent recognition pathways. Blood 82: 182-191, 1993. [Abstract] | ||||||
| von Andrian, U.H., Berger, E.M., Chambers, J.D., Ramezani, L., Ochs, H., Harlan, J.M., Paulson, J.D., Etzioni, A., and Arfors, K.-E. In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes. J. Clin. Invest. 91: 2893-2897, 1993. [Abstract] | ||||||
| 1992 | Top | |||||
| von Andrian, U.H. and Arfors, K.-E. Molecular mechanisms of neutrophil adhesion in vivo. In: Leukocyte Adhesion, Basic and Clinical Aspects. Gahmberg, C.G., Mandrup-Poulsen, T., Wogensen Bach, L. and Hokfelt, B. (eds.), Nova Nordisk Foundation Symposium No. 6: 153-164, 1992. | ||||||
| von Andrian, U.H., Hansell, P., Chambers, J.D., Berger, E.M., Torres Filho, I., Butcher, E.C., and Arfors, K.-E. L-selectin function is required for B2 integrin-mediated neutrophil adhesion at physiologic shear rates in vivo. Am. J. Physiol. 263 (Heart, Circ.Physiol. 32): H1034-H1044, 1992. [Abstract] | ||||||
| 1991 | Top | |||||
| von Andrian, U.H., Chambers, J.D., McEvoy, L., Bargatze, R.F., Arfors, K.E., and Butcher, E.C. Two step model of leukocyte-endothelial cell interaction in inflammation: Distinct roles for LECAM-1 and the leukocyte B2 integrins in vivo. Proc. Natl. Acad. Sci. USA 88: 7538-7542, 1991. [Abstract] [PDF] | ||||||
| Rosengren, S., Olofsson, M., von Andrian U.H., Lundgren-Akerlund, E., and Arfors, K.-E. Leukotriene B4-induced neutrophil-mediated endothelial leakage in vitro and in vivo. J. Appl. Physiol 71 (4): 1322-1330, 1991. [Abstract] | ||||||
| 1990 | Top | |||||
| Kempski, O., von Andrian, U.H., Schürer, L., and Baethmann A. Intravenous glutamate enhances edema formation after a freezing lesion. In: Advances in Neurology 52. Long D. (ed.), New York, Raven Press, p. 219-224, 1990. [Abstract] | ||||||
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