| Localization of distinct antigen-experienced CD8+ T cell populations in secondary lymphoid tissues. The figure shows four three-color confocal micrographs of cryostat sections of spleens (upper row) and peripheral lymph nodes (lower row) from recipient mice 24 hours after intravenous injection of TRITC labeled cytotoxic effector cells (left column) or central memory cells (right column). The sections were counterstained with anti-B220 (green) and anti-Thy-1.2 (blue) to localize B cell follicles and T cell areas, respectively. TRITC labeled homed donor cells are identified by red fluorescence. For details on differential in vivo trafficking of effector and central memory cells see the article by Weninger et al. |
