IDIImmune Disease Institute
Department of Pathology
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Lisa Anne Pitcher, PhD
Postdoctoral Fellow

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Lisa

Publications:

 

Sivakumar, P. V., Gunturi, A., Salcedo, M., Schatzle, J. D., Lai, W. C., Kurepa, Z., Pitcher, L., Seaman, M. S., Lemonnier, F. A., Bennett, M., Forman, J. and Kumar, V.  Expression of Functional CD94/NKG2A Inhibitory Receptors on Fetal NK1.1+Ly-49- Cells: A Possible Mechanism of Tolerance During NK Cell Development.  Journal of Immunology. 1999. 162(12); 6976-80.

Abbott, J. J., Pei, J., Ford, J. L., Qi, Y., Grishin, V. N., Pitcher, L. A., Phillips, M. A. and Grishin, N. V.  Structure Prediction and Active Site Analysis of the Metal Binding Determinants in g-Glutamylcysteine Synthetase. Journal of Biological Chemistry.  2001.  276(45): 42099-107.

Pitcher, L. A., Ohashi, P. S. and van Oers, N. S. C.  T Cell Antagonism is Functionally Uncoupled from the 21- and 23- kDa Phosphorylated Forms of the TCR z Subunit.  Journal of Immunology.  2003.  171(2): 845-52.
           
Sozio, M. S., Mathis, M. A., Young, J. A., Wälchi, S., Pitcher, L. A., Wrage, P. C., Bartók, B., Campbell, A., Watts, J. D., Aebersold, R., Hooft van Huijsduijnen, R. and van Oers, N. S.  PTPHI is a Predominant Protein Tyrosine Phosphatase Capable of Interacting with and Dephosphorylating the T Cell Receptor z Subunit.  Journal of Biological Chemistry. 2004.  279(9): 7760-7769.

Purtic, B., Pitcher, L. A., van Oers, N. S. C., Wülfing, C.  T Cell Receptor (TCR) Clustering in the Immunological Synapse Integrates TCR and Costimulatory Signaling in Selected T Cells.  Proceedings of the National Academy of Sciences. 2005.  102(8): 2904-2909.

Pitcher, L. A., Mathis, M. A., Subramanian, S., Young, J. A., Shores, E. W., Love, P. E., Wakeland, E. K. and van Oers, N. S. C.  Selective Expression of the 21-kDa Tyrosine Phosphorylated Form of TCR z Promotes the Emergence of T Cells with Autoreactive Potential.  Journal of Immunology. 2005.  174:6071-6079

Pitcher, L. A., Mathis, M. A., Durham, M. DeFord, L. M., Purtic, B., Wulfing, C. and van Oers, N. S. C.  The CD3 ge/de Module Provides Normal T Cell Functions in the Absence of the TCR z Immunoreceptor Tyrosine-Based Activation Motifs.  European Journal of Immunology.  2005.  35:3643-3654.

De-Ford-Watts, L. M., Young, J. A., Pitcher, L. A. and van Oers, N. S. C.  The Membrane Proximal Portion of CD3 e Associates with the Serine/Threonine Kinase GRK2.  Journal of Biological Chemistry.  2007.  282(22):16126-16134.

Pitcher, L. A. and Schaffer, P. A.  2006.  Cyclin D, but not Cdk2/Cyclin E Complexes are Required for Efficient HSV-1 Replication.  In preparation.

 

Reviews:

Pitcher, L. A., Young, J. A., Mathis, M. A., Wrage, P. C., Bartók, B. and van Oers, N. S. C.  The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR z subunits.  Immunological Reviews.  2002.  191: 47-61.

Pitcher, L. A. and van Oers, N. S. C.  T Cell Receptor Signal Transmission:  Who Gives an ITAM?  Trends in Immunology.  2003.  24(10): 554-60.